Asbun demonstrated in results from the KATHERINE trial

Abnormal results of investigations (e.g., laboratory studies of blood camples) were the most common adverse event, followed by cardiac disorders and nervous system disorders. Of patients treated with T-DM1, 9 experienced abnormal results of investigations, 5 experienced cardiac disorders, and 4 experienced nervous system disorders. Five cases each of abnormal results of investigations and cardiac disorders were present in the trastuzumab group, with no nervous system disorders occurring in this group.

Seven-year invasive-disease-free survival and seven-year overall survival rates in the immunohistochemistry (IHC) 2+ subgroup were 72.4% and 83.3% on T-DM1.

“These findings warrant evaluation of additional or alternative therapies to improve outcomes for these patients, including those who had initially presented with inoperable disease, those with positive axillary nodes after neoadjuvant therapy, and those with both IHC 2+ and ISH-amplified disease,” said researchers.

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