Adjuvant trastuzumab emtansine (Kadcyla; T-DM1)
USA
Technology
+44018956955324
2ntakh934o@illubd.com
Added on 28 Mar 2025
6-9 The Square, Stockley Park, Uxbridge, Middlesex UB11 1FW
Business Description
โThis prespecified long-term follow-up analysis provides additional support for the neoadjuvant therapy paradigm by showing that adjuvant T-DM1 also provided a significant improvement in overall survival and no evidence of long-term safety issues,โ wrote KATHERINE investigators in The New England Journal of Medicine.
Patients enrolled in the phase 3, open-label trial continued to see an improvement in invasive disease-free survival with T-DM1 vs trastuzumab at a median follow-up of 8.4 years (unstratified HR = 0.54; 95% CI, 0.44-0.66). Particularly, 19.7% of patients in the T-DM1 group and 32.2% of patients in the trastuzumab group experienced invasive disease events or death.
Seven-year invasive disease-free survival was achieved in 80.8% of patients treated with T-DM1 and 67.1% of patients on trastuzumab (difference, 13.7 percentage points).
The trial included patients with HER2-positive early breast cancer who had received neoadjuvant treatment, which included a taxane-based chemotherapy and/or trastuzumab, and had residual invasive cancer in the breast or resected axillary nodes. Patients were randomly assigned to receive either T-DM1 (n = 743) or trastuzumab (n = 743). Patients were stratified by clinical stage, hormone-receptor status, preoperative HER2-directed therapy, and pathological nodal status after neoadjuvant therapy.
T-DM1 significantly reduced the risk for death compared with trastuzumab (unstratified HR = 0.66; 95% CI, 0.51-0.87; P = .003). Seven-year overall survival for the T-DM1 and trastuzumab groups were 89.1% and 84.4%, respectively (difference, 4.7 percentage points). As of the trialโs cutoff date of October 5, 2023, 70.1% of patients assigned T-DM1 and 62.0% of patients assigned trastuzumab were alive and still in the trial.
Deaths occurred in 89 patients (12.0%) in the T-DM1 group and 126 patients (17.0%) in the trastuzumab group. Of these deaths, 70 (79%) and 108 (86%) patients, respectively, died from breast cancer.
Adverse events (AEs) grade 3 or higher occurred in 26.1% of patients treated with T-DM1 and 15.7% of patients treated with trastuzumab. Serious AEs occurred in 12.7% and 8.1% of patients, respectively.
Post-treatment AEs were less common for both groups but still more prevalent in the T-DM1 group, with 3.2% and 1.7% of patients assigned T-DM1 and trastuzumab, respectively, experiencing AEs of any grade during this period.
https://www.twosapp.com/67e5bc42795e95113cfa23a6
https://talkfever.com/posts/36877
https://hallbook.com.br/posts/514191
https://wegug.in/posts/54582
https://forum.phuongnamedu.vn/threads/nanonano-mencretcalan-ciritlele.8344/
https://dangtinvantai.com/threads/nanonano-mencretcalan-ciritlele.63658/
https://chobaolam.vn/threads/nanonano-mencretcalan-ciritlele.633132/
https://choitrai.net/threads/nanonano-mencretcalan-ciritlele.50203/
https://chodilinh.com/threads/nanonano-mencretcalan-ciritlele.456427/
https://diendannhansu.com/threads/nanonano-mencretcalan-ciritlele.754834/
https://ecency.com/cocot/@susutjitangvi/nanonano-mencretcalan-ciritlele
https://forum.thecodingcolosseum.com/topic/49810/nanonano-mencretcalan-ciritlele
https://foro.ribbon.es/topic/66767/nanonano-mencretcalan-ciritlele
https://icimodels.com/advert/nanonano-mencretcalan-ciritlele/
https://haitiliberte.com/advert/nanonano-mencretcalan-ciritlele/
https://feiradevelharias.com/advert/nanonano-mencretcalan-ciritlele/
https://taylorhicks.ning.com/photo/albums/nanonano-mencretcalan-ciritlele
https://healingxchange.ning.com/photo/albums/nanonano-mencretcalan-ciritlele
https://findaspring.org/members/susutjincine/
https://bootstrapbay.com/user/acisampeuedol
https://nexusstem.co.uk/community/main-forum/nanonano-mencretcalan-ciritlele/
https://www.deviantart.com/stevianaomi/journal/nanonano-mencretcalan-ciritlele-1176063173
https://app.daily.dev/posts/nanonano-mencretcalan-ciritlele-1k8ebenju
https://hackmd.io/@stevaniachaw/rJ7WHSmT1g
